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Phytochemical Screening of Some Anticancer Designate Medicinal Plants of Polypetalae

Minhajur Rahman
Department of Botany, University of Chittagong, Chittagong, Bangladesh

Ataur Rahman
Department of Botany, University of Chittagong, Chittagong, Bangladesh

ANM Alamgir
Department of Botany, University of Chittagong, Chittagong, Bangladesh

Abstract/ Executive Summary:

Phytochemicals are the dependable sources for the treatment of different health problems. Anticancer medicinal plants possess cancer healing property due to their bioactive metabolites of secondary origin. The present work revels phytochemical screening of 23 anticancer medicinal plant species representing 17 families of Polypetalae for alkaloids, flavonoids, sterols, tannins, glycosides and saponins. Except Phylanthusas amurus, alkaloids were present in all plant species while flavonoids, sterols, resins, tannins, glycosides and saponins were present in 17, 12, 5, 13, 15 and 10 plant species, respectively. Results of the screening work on secondary metabolites were discussed in relation to their abundance and distribution in different test plants and their organs.

Keywords: Anticancer plant, Phytochemical screening, Secondary metabolites, Polypetalae

Location: Hilly campus of Chittagong University and its surroundings.

Start Date:

End Date:

Program Area: Development of Host and Medicinal Plants

Commodity: Medicinal Plants

Objectives:

Considering the importance of natural products in cancer therapy, in the present work, 23 anticancer designate medicinal plant species of Polypetalae were subjected to phytochemical screening for their secondarymetabolites.

Methodology:

Twenty three anticancer designate medicinal plant species of Bangladesh representing 17 families of Polypetalae, reported in published literature, were considered in the present work for phytochemical screening for alkaloids, flavonoids, sterols, resins, tannins, glycosides and saponins. These plants were collected from the hilly campus of Chittagong University and its surroundings, identified and their voucher specimens (accession no. 2010-01-23) were kept in the department. For alkaloids, the modified method of Webb (1949) was followed according to Amarasingham et al. and Apline and Cannon . Five alkaloid detecting reagents, e.g., Dragendorff (D), Wagner (W), Mayer (M), Hager (H) and Tannic acid (T), prepared followingCromwell, were used. Flavonoids were determined in the Et-OH extract following Wall et al.and Farnsworth. Sterols, tannins, glycosides and saponins were assessed following Bhattacharjee and Das, Wall et al. and Eyjolfesson, respectively. The absence, presence and abundance of different secondary metabolites in the test samples were indicated by –, + and multiple of + signs, respectively. Each test was replicated thrice.

Source of Information: Journal of Pharmacognosy and Phytochemistry 2017; 6(2): 177-180

Article Link (Online Journal):

Funding Source:

Budget:

Total Budget (Tk.) :

Achievement/Findings:

Results of the present work suggest uneven and sporadic distribution and abundance of the secondary metabolites in different plant species. The contribution of plants to treat cancer is enormous and high number of new drugs is currently being evaluated in clinical trials. Vinca alkaloids, taxanes, combretastatins, podophylotoxins and camptothecins are some important examples of some natural products useful for cancer

Knowledge Management: Journal